|Through several screening studies of natural compounds identified quercetin as a promising
candidate targeting the SARS-CoV-2 through
two mechanisms which are as follows:|
QUERCETIN BLOCKING OF VIRAL ENTRY. QUERCETIN POTENTIAL SUPPLEMENT IN COVID19 TREATMENT.
1. Prevention of virus from entering the host cell through inhibition of ACE-2. The interaction of Angiotensin Converting Enzyme-2 (ACE-2) with viral spike protein is a critical initial step for the entry of virus to the human host cell.
2. Inhibition of cysteine proteases, 3CLpro & PLpro. The viral main protease Mpro or 3-chymotrypsin like proteases (3CLpro) and papain like protease (PLpro) controls the activities of the coronavirus replication complex.