COVIDEX

Natural Anti-viral Combination for Phrophylaxis & Treatment of COVID-19


QUERCETIN for the Treatment of COVID-19. Quercetin is a multipotent bioflavonoid with great potential for the prevention and treatment of disease. Quercetin is said to be one of the most widely used bioflavonoids for the treatment of metabolic and inflammatory disorders. Quercetin glycosides are metabolized, absorbed, and circulated as types of conjugates in the blood. Thereafter, quercetin-3-O-?-D-glucuronide (Q3GA), a major metabolite of quercetin, is distributed throughout the body where it may exert beneficial functions in target tissues.

Through several screening studies of natural compounds identified quercetin as a promising candidate targeting the SARS-CoV-2 through two mechanisms which are as follows:
QUERCETIN BLOCKING OF VIRAL ENTRY. QUERCETIN POTENTIAL SUPPLEMENT IN COVID19 TREATMENT.
1. Prevention of virus from entering the host cell through inhibition of ACE-2. The interaction of Angiotensin Converting Enzyme-2 (ACE-2) with viral spike protein is a critical initial step for the entry of virus to the human host cell.
2. Inhibition of cysteine proteases, 3CLpro & PLpro. The viral main protease Mpro or 3-chymotrypsin like proteases (3CLpro) and papain like protease (PLpro) controls the activities of the coronavirus replication complex.

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